Independent and cooperative motions of the Kv1.2 channel: Voltage-sensing and gating
نویسنده
چکیده
4 Introduction 5 Methods 8 Structure 8 Elastic Network Models 9 Evolutionary Conservation 9 Results 11 a. hinges and rigid elements 11 GNM 11 ANM 13 b. The correlation between the fluctuations 13 Identification of motions in groups of slow modes 13 The PD 16 The motion of the VSD 17 I. The hinge between the domains 17 II. The S4 helix 18 III. Other hinges in the VSD 19 Independent motions of the VSD 20 Correlations and cooperative behaviour 20 Motion of the tetramer versus motion of the isolated monomer 20 The infulence of the sensor on the pore 23 Correlations between the motion of the gate and the VSD 23 The motion of the S1 helix 25 Discussion 27 References 30 Appendix 35
منابع مشابه
Independent and cooperative motions of the Kv1.2 channel: voltage sensing and gating.
Voltage-gated potassium (Kv) channels, such as Kv1.2, are involved in the generation and propagation of action potentials. The Kv channel is a homotetramer, and each monomer is composed of a voltage-sensing domain (VSD) and a pore domain (PD). We analyzed the fluctuations of a model structure of Kv1.2 using elastic network models. The analysis suggested a network of coupled fluctuations of eigh...
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